
	论坛时间：2019年11月5-8日论坛时间：2019年10月21-25日

论坛宣言
Declaration

组织机构
Department


	2007年11月5日至7日，来自澳大利亚、美国、加拿大、日本、匈牙利、中国等财神手机版下载最新优惠的近百名农业科学家聚会中国杨凌，以“国际农业合作、创新与发展”为主题，就旱区农业与节水农业、高效畜牧业与动物疾病防控、食...
	【点击查看更多内容】

2015

主页» 杨凌国际农业科技论坛» 论文摘要» 2015

The target and its underlying mechanism of herbal polysaccharide with anti-cacer bioactivity

发布时间：2015-11-01 来源：

Kan DING
Glycochemistry & Glycobiology Lab,
Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
555 Zu Chong Zhi Road Pudong, Shanghai 201203, China
Glycans attached on glycoprotein and proteoglycan as receptors on cell membrane participate in cell signaling involved in molecular events related in disease development. Glycan mimetics from plant and fungus may work as a probe to understand angiogenesis implicated in cancer or as drug candidate to interfere cancer cells growth.
We find that 1,2-linked glycan induces FGF2 expression and promotes angiogenesis. 1,3-linked glycan may bind to dectin-1 and trigger immune system to inhibit tumor cells growth. 1,4-linked glycan interacts to BMP2 and its receptors to impair tumor angiogenesis. Some of them may target multiple angiogenesis factors such as EGF, VEGF, BMP2, BMP4, galectin-3 to attenuate angiogenesis and further impede tumor growth in vivo. The structure of glycan is the important factor that may influence the binding affinity. However, the Kd value of such binding is not as strong as small molecule to protein. This might be one of the reasons that glycan are not very toxic as that of some of small molecules. This suggests that glycans from herbal medicine might be a good candidate for new drug development for tumor therapy.

上一篇： $article.name
下一篇： $article.name

论文摘要

${curChannel.parent.path}

相关阅读

站点导览