
	论坛时间：2019年11月5-8日论坛时间：2019年10月21-25日

论坛宣言
Declaration

组织机构
Department


	2007年11月5日至7日，来自澳大利亚、美国、加拿大、日本、匈牙利、中国等财神app下载帮助中心的近百名农业科学家聚会中国杨凌，以“国际农业合作、创新与发展”为主题，就旱区农业与节水农业、高效畜牧业与动物疾病防控、食...
	【点击查看更多内容】

2015

主页» 杨凌国际农业科技论坛» 论文摘要» 2015

Nutraceutical properties of tetraploid Jiaogulan (Gynostemma pentaphyllum)

发布时间：2015-11-01 来源：

Liangli Lucy YU
Department of Nutrition and Food Science, University of Maryland
Gynostemma pentaphyllum (Chinese name: Jiaogulan) has been used as functional tea worldwide. Commercially used Jiaogulan are mostly diploids, whereas tetraploids have been cultivated and were commercially available. Our previous studies have shown significant differences in flavonoid and saponin compositions and bioactivities between the tetraploid Jiaogulan and its diploid counterpart. Jiaogulan showed several health benefits including anti-inflammatory and antiobesity activities, and its saponins were considered as the major health constituents. As a continuation of our Jiaogulan research, the chemical constituents of saponin-rich fraction in tetraploid Jiaogulan were investigated. Six new 21, 23-epoxydammar-24-ene saponins and two novel 21-nordammarane saponins were isolated and elucidated by HRESIMS, 1D and 2D NMR data, chemical degradation and electronic circular dichroism (ECD) spectra. All isolated saponins suppressed the expression of IL-1β, COX-2 and TNF-α mRNA in the lipopolysaccharide-induced RAW 264.7 mouse macrophage cells at the concentrations of 10 and 100 μg/mL, suggesting their remarkable anti-inflammatory effects. In addition, a saponin also showed significant anti-adipogenic activity through down-regulation the expression of major genes involved in the adipogenesis pathway and up-regulation the WNT/b-catenin pathway. The results may be used to promote the value-added utilization of Jiaogulan and its components in reducing the risk of chronic inflammation and obesity.

上一篇： $article.name
下一篇： $article.name

论文摘要

${curChannel.parent.path}

相关阅读

站点导览