Jian-Min Yue
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zhuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203 P. R. China
Chemical studies on a large number of Chinese medicinal plants (including TCM) have led to the identification of a big array of structurally interesting and/or bioactive components (1−8), e.g. anticancer, antiHIV and immunosuppressive agents [1,2]. Some compounds have been selected as lead structures for our drug development program, and over one hundred of modified chemical entities with significantly improved activities were also obtained; biological evaluation showed that some of the compounds exhibited remarkable anticancer (both cytotoxic and antiangiogenesis), immunosuppressive and antiHIV activities; several groups of bioactive compounds showed very clear structure activity relationships; A few of structurally interesting and biologically important compounds have been synthesized [2]. Our studies have provided good scientific background for drug development and understanding of the function and toxicity of the involved medicinal plants.
References
1. For reviews on structurally diverse and biologically active natural compounds, see a) Hua Zhang, Hong-Bing Liu, and Jian-Min Yue, Chem. Rev., 2014, 114, 883. b) Sheng-Ping Yang, Jian-Min Yue, Acta Pharm. Sin., 2012, 33, 1147. c) Shang-Gao Liao, Hua-Dong Chen and Jian-Min Yue, Chem. Rev., 2009, 109, 1092.
2. a) Yao-Yue Fan, Hua Zhang, Yu Zhou, Hong-Bing Liu, Wei Tang, Bin Zhou, Jian-Ping Zuo, and Jian-Min Yue, Phainanoids A–F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis, J. Am. Chem. Soc., 2015, 137(1), 138-141. b) Jin-Biao Xu, Hua Zhang, Li-She Gan, Ying-Shan Han, Mark A Wainberg, and Jian-Min Yue, J. Am. Chem. Soc., 2014, 136, 7631. c) Hua Zhang, Chuan-Rui Zhang, Kong-Kai Zhu, An-Hui Gao, Cheng Luo, Jia Li, and Jian-Min Yue, Org. Lett., 2013, 15, 120. d) Bo Zhang, Yao Wang, Sheng-Ping Yang, Yu Zhou, Wen-Bin Wu, Tang Wei, Jian-Ping Zuo, Ying Li and Jian-Min Yue, J. Am. Chem. Soc., 2012, 134, 20605. e) Yao Wang, Quan-Fang Liu, Ji-Jun Xue, Yu Zhou, Huang-Chao Yu, Sheng-Ping Yang, Bo Zhang, Jian-Ping Zuo, Ying Li, and Jian-Min Yue，Org. Lett., 2014, 16, 2062-2065. f) Jia Liu, Xiu-Feng He, Gai-Hong Wang, Emilio F. Merino, Sheng-Ping Yang, Rong-Xiu Zhu, Li-She Gan, Hua Zhang, Maria B. Cassera, He-Yao Wang, David G. I. Kingston, and Jian-Min Yue, J. Org. Chem., 2014, 79, 599-607.g) Sheng-Ping Yang, Xiao-Wei Zhang, Jing Ai, Jin-Biao Xu, Bo Zhang, Zu-Shang Su, Ying Wang, Lu Wang, Jian Ding, Mei-Yu Geng, and Jian-Min Yue, J. Med. Chem., 2012, 55, 183-8187
|
